One of the biggest things that changed for me was getting carpal tunnel and having to stop doing art for a year. It really gave me perspective on how I was using my hands and how much I was wasting my time in my art process.
I used to render too much when I was younger, and was certain I had to have a unique "style" that encompassed everything I made. Which, at the time was a messy Tim Burton aesthetic with a very long mixed media process that involved sketching by hand, then scanning, then doing more on the computer, then printing, then using gesso and water to transfer the print to a board and then painting over that with acrylic and then maybe even using oil paint and colored pencil on top of that. Ridiculous.
Now I've realized that every project dictates it's own style depending on it's needs, and that doing things more complicated to either conform to trends or impress people with my exhaustive process does not mean that they're better. Maybe it's part of turning 30 but I'm a lot more confident and no longer driven to impress everyone by everything I do, and so I can let go and do projects that are just lineart with some grayscale, like my current comic, while still doing very detailed paintings in other places I work.
I'm no longer terrified of posting mistakes or flaws--After all those years of carpel tunnel, I'm just glad I'm posting anything at all. And it's taken so many years, but I've finally realized people who see my art and read my stuff realize I'm only on a step of my own journey, and they don't expect me to be perfect, either.