Sketch on paper, scan it, put it on photoshop cs6, and then draw with the pencil tool (not brush).
Coloring is actually the easiest. All I have to do is select inside the drawings, add new layer under, and use a paint bucket tool with anti-alias off and tolerance at 0. Sometimes I make a layer above and draw the shades. Most of the time I just draw it with the color layer. Then add text above all layers with speech bubbles or not.
-- text -- 5th
--outlines-- 2nd
--shades-- 4th
--coloring-- 3rd
--sketch-- 1st
Sometimes I have the habit of merging and publishing.