I'm not entirely sure I'd call any of my antagonists villains...
The dynamic that develops is of these two sides (the protagonists consisting of Atria Silversword, Princess Stella, and Captain Infinite; and the antagonists consisting of The Destroyer, Jenny Calhoun, and, as of next week, Jack Death) clashing over the power source the Destroyer stole from Atria's world (which is on the path to detonating and taking out a huge chunk of Tokyo in the process). There is a process of radicalization happening with the antagonists that will lead the conflict to change in its nature, but, if I've done my job right, by the time the last battle is finished the reader won't be entirely sure if the protagonists were on the right side in the first place.
So, it is pretty much these two sides colliding, separating, and then colliding again, with each confrontation becoming more intense (nobody has been seriously hurt yet, but that IS going to change).