For me, I need an interesting premise and I MUST like at least one of the main characters - not as a friend, but as an interesting character to watch.
After that, similar to Oriflamme, it needs to not hit my drop flags - isekai, video-game style worlds, litRPG, being smut/porn, cliche setting, poor art, excessively political, being anti- my ethnic/religious group (or by being anti-any real-world group really). Maybe I can handle one of these things, if there's enough positive to offset it. If your fantasy fiction starts with cosmic level creation of the world, I'll roll my eyes and stop reading.
If I like the characters and feel like the story is making good on its promises, I will keep coming back!