Not a webcomic maker, but a writer here.
After a decade of writing, I have only just learnt that planning and preparation is everything. Do your homework, set out your storyline and characters, ask for opinions and proof-write two to three chapters before you even start to publish.
Otherwise you may find yourself having to restart, or abandon the work completely when you inevitably lose track of what you did and where you are going.
Endeavours like these take years, and your memory can't keep track of all that. So be sure to plan wisely