Working in traditional page layout! The more I struggle with it, the less I like it. I'd prefer to work vertically, and adapt vertical panels to page layout later for printing... but my iPad doesn't handle working at such high resolution without lagging like heck (Clip Studio) or restricting the amount of layers I can use. (Procreate.)
I know I want to be able to print my comic, so being able to adapt anything I make for print is extremely important to me. And since I'd need to be able to stretch panels across the page, my vertical canvas would need to be at least 2000px across, at 300dpi. And my iPad just... will not.
Clip Studio will give me an adequately sized canvas, but the instant I add paint-y texture and colour jitter to a brush it nopes the hell out. Procreate is all like "Sure, here's all your nice brushes and a big canvas, but you can have like... 10 layers. Have fun with that."
So I persist in working in page format, despite the fact that it slows me down and frustrates me, then adapting panels to vertical, because tech limitations mean I can't work the opposite way around.