High-five to all my health buddies. I have an unknown nerve issue with my hands where they randomly get in pain. So... I take it slow. It takes me 10-15 hours of drawing per page (which is an episode), and I can do that in just under two weeks, which gives me a couple days of wiggle room if I'm feeling sick or if I just want to draw fan art or something one day.
I decided to not take shortcuts (beyond the stylistic simplification) because I'd rather this be something I did lovingly for fun. You know, like a statue that you just whittle away at as a hobby. I estimate Engram will be about 120-130 pages in total (I have the rough plot from start to finish already done) so I'm (mostly) fine with the pace I'm working at. The writing and plotting I do in micro bursts over the course of months, but it took me a couple days to plot a chapter that will take months to draw so I'm not too worried about my writing speed, though typing more than 600 words a day hurts (I use the dictation tools on my iPad sometimes, but it only works for planning, not for actual writing).
The most time-consuming part for me is honestly the planning phase. The layout, sketching, finalized dialogue... Once I have all that down, I can just work on it like clockwork. The second slowdown is usually when I get to the flat colors because I just don't know wtf I'm doing so I just flop around until I accidentally find aesthetically-pleasing colors that match the composition. Once those are settled, the rest is smooth sailing. So, I guess if I figured out how to better do the visual development part of the comic, I'd be probably 30% faster....
I'm a bit stuck right now because I developed a chronic migraine right when I needed to draw the second-hardest chapter of this comic (a sci-fi megapolis, which is something I'm weak at....) so I'm going to be slowing down to posting once a month until I can work through this.
I created a buffer of about two months for myself so that takes some of the stress off. Also, if you have health problems, to avoid burnout I recommend you be realistic about how fast you can work and set your publication speed (i.e. your self-imposed deadline) to be a bit slower than that. Like, it technically takes me ~12 days to finish a page, but I publish every 15. Best case scenario you keep adding to your buffer - and you can always release bonus episodes. Worst case scenario, you got breathing room for when you feel like crap.