Well I got a series of comments from a person who pretty much only ever commented to judge my life decisions and push me down. When I mentioned how screwed up the medical system is here in sweden (and across the rest of the world really) when it comes to how they handle trans people, this person just slapped my face with "the waiting for transition SHOULD be really long". Mind you this was during a time that it was well known my shitty situation brought me to suicidal thoughts. It was the last thing I needed to hear in that moment, and certainly not something the huge amount of trans people in my audience needed to see. I confronted them about it, and they straight up told me they just dislike transgender transitions and piercings/body modifications (oh yes. They judged me for my lip piercings too.)
I don't get comments from this person anymore, thank god. It was the only time I had to straight up tell a person I wanted them to stop coming around for my comics and that I would block them if I could. As I said, I have a lot of transgender readers, I can't have transphobic people hanging out in the comments.