It's a very attractive design, I think they're mostly interchangeable depending upon placement. You can use the white or black background based on the surrounding elements. And I agree with @joannekwan about the colored one having a lighter connotation- it's kind of prep/pop ish so if that is relevant to the tone of your comic it could be good. I like the black on white/white on black best over all though.
(also agree that the box doesn't really add anything to it)