The protagonist from my comic Voidchild isn't based on any one thing in particular.
She was actually part spawned from a strange bug in a now cancelled mmorpg "City of Heroes" wherein I came up with her backstory and concept. I was playing the beta after I made the character, who was originally male. Then the next time I started it up he'd been gender-swapped and I basically went: "hey, she looks much cooler than that other guy" and stuck with it. ^_^
She does draw some inspiration in demeanour from the character Samuel Aran of the Metroid series. A character I deeply love as a no-nonsense, mysterious character who also manages to feel involved, loving and caring despite a detached persona. But it was never the point to emulate Samus. I think aspects of her just worked her way into Mary as I fleshed out the character. And in case anyone is wondering I do consider Metroid: Other M some form of crime for how they treated my favourite video game protagonist of all time...