I guess I feel like it's a bad idea to react with defensive anger. I don't feel like it's my place to decide what's "called for" or not.... like, if you're creating a comic for free, and people are responding to it a way that you don't like, you get to be frustrated and angry and ask folks to leave, if that's how you want to respond. I just don't think it's a good idea or the best thing to do, to make your work a place of hostility.
But at the same time, that's how art works, my dude. You make art and people make it a part of themselves. People tag your personal characters as "kin" and project on the people they like and misinterpret them. You have to come into this with your eyes open, knowing you won't be able to control that. Some people get really frustrated over the fact that they can't both share their work and keep it totally under their control.
One creator made a story based on an actual abusive relationship she experienced, and then her fans shipped those characters together. I don't think it's helpful to crack down and tell those people to stop, but I know it must be hard to take it with grace when people refuse to see what you're trying to say.
As nice as this kind of thing sounds, I think for a lot of creators, boundaries are important! It's easy for readers who follow your work every day to forget they don't really know you, and that you don't know them, which sometimes leads to kind of uncomfortable interactions or unfair requests. I think it's okay to strive for a happy medium; you don't have to be friends to be friendly with each other!