Mind if I share one of my favorite comments placed on my anthro series (because it sums up a lot of points here):
No matter what, some people are going to have a bias toward something in your comic. And yeah, Anthro can be a definite "no" from some people and merely a hesitation with others (and a "hell yes!" from others too). It's the writing or art (or both) that are going to pull you across the finish line with readers.
Every comic has limitations on its fandom. So I wouldn't let that stop you from making the comic you want to make.
But, this isn't your first rodeo either. You have comics out there. You have readers. But if you want to branch out and see if you can pick up new readers- why not try an experiment? You can always do a poll featuring concept art in both styles (as long as you can live happily with either style) and see what more people are attracted to.
No matter what, always stay true to yourself. Your base (both future and current) loves you for you. But if you could do either style happily- why not try something new if that's where the winds are blowing you. Blind adherence to your preferences might just be navel-gazing... but it might also be exactly where you need to be.
If you're up to letting other people dictate where your style should go, I would suggest doing a poll here and getting more eyes on it in general to better inform your decision.
If you have one style you really want to do, do that (your heart will attract other hearts).
It may be a touch skeptical-sounding, but my day job is making beer packaging and I often do the same job in 3 different styles before we land on a winner. And sometimes something that didn't seem like a big deal to me in the design was so eye-catching/important to someone else. You never know. And getting out of your comfort zone will provoke growth.
As long as you're on the path you want to be on, stay on the path. Sometimes either path in the fork in the road will still get you to where you want to go. If you have a clear goal in mind, get there anyway you can.