I'm the weirdo who draws all of my BG's by hand digitally (and I eyeball most of my perspective grids, lol)... However my characters are super simple, cartoony and a little bit lopsided so I honestly don't know how I'd integrate 3D assets in a way that looks organic. I may have to just have a perspective mesh in a couple chapters that take place inside of a spherical spaceship just because it's messing with my head to try and puzzle it out, but... Otherwise I feel like I don't waste too much time drawing it by hand?
For a comic I never launched, I had like, a "panoramic" shot of a room (all of the walls stretched out as a single image) that I was plopping into panels that only needed the bare suggestion of a background.
For Engram, I started out putting backgrounds in almost every panel, but that kids is not a good way to draw a comic fast, lol. Now I try to keep it to a maximum of 1 large or two smaller panels with an actual background, one or two more with a basic background, and the rest with just a solid color.