Like most answers here, I generally only skip to the latest ep (or somewhere in the middle) if the art style or vibe isn't matching with the series banner/thumbnail. Then I'll take a quick 5-sec glance at the first frame/page of that latest ep, to avoid knowing the contents.
I'm less afraid of spoilers than starting a series in a way not intended by the creator(s). Not like there's any rule that dictates how a story should be read, but I can't help but feel a bit disrespectful for doing so 
By the way, I might be deviating a bit, but just curious if anyone feels conflicted as a creator to have new readers start from your latest ep vs. the beginning because your art style improved significantly over time, esp. for not-so-episodic series 