Well let see....
Do you remember Kungfu Panda?
There's a character that is literally a bug that uses his speed, giving his mantis claws and feet to deal damage to his opponent whereas the panda uses his excess girth in combat.
I guess what I am trying to say is that smaller guys tend to use speed and overall dexterity to win. But I do feel the trickier part is to depict the motion and speed of the characters in a fight as a comic in general is a still image.