It is a bit early to reveal the "big bad" of everything, but Fang does already know his eventual enemy.
My MC knows him quite well but doesn't know that hes is evil and therefore can't really comprehend their power.
The big bad guy isn't one specific person, but MC does (or will soon know at least) the big bad's hench-woman 
My MC doesnt know the big bad yet, but it'll be fun figuring out how they'll get to meet each other for the first time
Without spoiling too much, I will say the MCs of my comic know the big bad a little bit.
At this point however, they haven't even shown up.
My Mc doesn't really know who the big bad is (yet), but he will find out pretty soon. The one who ruined his and his family's life, the monster who made them suffer, will be revealed to him. Though my villain might not seem very original, I assure there is more to his character, and he's probably one of my favourites among the cast!
For Clara, she initially didn't know who the true big bad was, but as she digs through her mother's cold case, she ends up discovering much more than she bargained for. Currently, she does know who that villain is, but she's taking her time for her sweet revenge 
(And yes, there's a ton of drama in my novel 
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My MC does in fact know my big bad (of which there are a few). HOW she knows them is actually something I don't want to spoil just yet, but it's a person somewhat close to her she doesn't suspect.
Technically, my MC has met the big bad, but she doesn't know them...the how of that is a huge spoiler though so I can't say much about it 
In Izzy!; the current, ongoing story arc entitled "The Power Of Friendship" has introduced other kinds of gnomes who mainly focuses on adventures and heroism. Izzy is not aware of the looming threat of the series's current villain a.k.a. the Dark One. However, being curious and friendly that he is, despite not having the proper training nor experience to handle such a dangerous task, Izzy had his fate intertwined with a party of gnomes who already knew each other before the quest began. And so... the story unfolds...
Ooof in my comic the big bad is such a big spoiler I don't wanna reveal anything about him at all. XD All I can say is that yes, he does know the main protag. There are a few minor villains too, the MC isn't a big fan of them. XD
For my Star Wars comic, KIRA: A Star Wars Story, the main character, Kira does know the villain. The villain, Zur'por was the Padwan learner of Jedi Master Kazu Tyrbus. As a baby Kira was adopted by Master Tybus, but Zur'por believed this goes against the Jedi code because Kira real father was a Sith Lord. Zur'por and other Jedi left the Jedi Order to form the Order of Purifiers, to remove any Jedi they deem not fit to be a Jedi.
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For my comic Geeking Around: The Webcomic, there isn't really a villain. The webcomic is just based my podcast Geeking Around: The Podcast, featuring myself and cohost/friend Gabby as anime characters. If I had to choose a villain for GA it would be fake fans. As a kid I was bullied a lot for liking comics, video games, anime, Star Wars, etc. While went to the premieres of The Avengers and Star Wars: The Force Awaken, who did I see? The exact same people who used to bullied me for liking it, now claiming they have always be fans.
In my story there isn't a "big bad" but more of like... internal things, such as past experiences, insecurities, and several of other things. My Main Characters, one to be specific, is very marked over his own childhood and the way his parents rised him and that can be reflected on both his behaviour and how he deals with the baby that magically appeared in front of him.
So here it is "We bumped into each other and had a baby", a heartwarming story focused on Co-Parenting.
Well, Nadhine feels like she knows her big bad, but she might not know him at all. She believes it's the Sultan Kaspar, because of all he did to her parents and to her people. However, she may soon find out her big bad is someone much closer to home...
Iris still hasn't got to the point of having a face-off with the big bad or any petty bads. Although she knows who will eventually be on the opposite of the ring when the time comes. She's a royal, she knows she and her siblings will one day fight for the throne.
1 month later
Alfredo already faced (Or rather, had a glimpse) his Big bad the day he was separated by his mother... and that is not only the ruler of the empire... but his mother's twin brother... someone very dedicated in keeping an "Order", to which Alfredo appears to be a threat to.
GENRE: Fantasy, Sci-fi Drama
From the nights He used to spend by reading tales of "the Dreamers", the young Alfredo Ananda Kasem always longed to be one of them as well, unaware of the Potential that resides in his Echo, that could change the lives of those around him, whose Stories, connected to His, are the KEY to bring changes to the World of Gaia, and lead to its peace once and for all.
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(Trying to be as non-spoilery as possible)
Technically, I would say I have a two big bads -- a "Villain" and an "Antagonist" -- and each of them has a different major conflict. That probably sounds complicated but I can explain. The "Villain" has a grudge against the MC and that led them to send an assassin after him before the beginning of the story and again when they find out the MC is still alive. Meanwhile the "Antagonist" has less of an "I hate you, you hate me so let's fight" scenario and they're just the leader of a country that's at war with the country the MC is in. To actually answer the question, yeah, the MC knows both of them but I can't say how because their identities are hush hush.