I would advise using Sims 4 only within a small scope. I myself will build sets for backgrounds in my comic, then screenshot the angle I need, and from there strip the lines and draw over any changes to make quick background line work, similar to how many comic artists use 3D modelers. However, the the characters, colors, and even much of the line art itself is revised to fit within my art style. While the Sims 4 can be great for set building, perspective angles, and even figuring out character outfits, I don't recommend using it for the entirety of a comic,.
This is not just because the art itself would not be coming from you, but rather a company as well as possible modders, but EA is also extremely intense over copyright infringements. While it has worked for telling stories in a blog format or on youtube videos, I don't think it would fair well in a webcomic format.