When I started my comic, it really helped add some structure into my life. Got plenty of that now, but at the time, I was in a bad state, and I do feel like it helped me get back into a better mental state. =)
Honestly, it might sound hokey, but I find thinking of my comic as "for me first" to be a really helpful state of mind. I still work hard, even have a patreon, but this way of thinking genuinely helps me have less anxiety about it all.
(It's more about anxiety than depression for me, though)