Yes, and no.
From what I've heard from popular Twitter users in general (not many artists...big artists don't usually talk about their own popularity, not even critically, which is kind of a shame) they often need to turn off notifications just so they don't have their phone going off every second for 2 straight days. ^^ So even if they want to obsess over every bit of attention they get, at some point it stops being feasible.
But they do notice things like a post going from 12K likes to 32K likes, for example. They have their own thresholds for how well their posts are doing just like the rest of us; they're just bigger. And when they increase fast enough, taking notice of every increase of 1 becomes difficult long before it becomes pointless.
I think novelty should also be taken into account...so the only place where I can even begin to think like this about my audience is my fan animation YouTube channel, whose first video is slowly working its way to 200K views (no telling when it'll get there; it's pretty old).
And I still look at the view counts from time to time, at least to see if 195,739 is getting any closer to that big round number. ^^; And I check for new comments almost every day.
It's a bad habit, yes, but it also shows that I'm not yet at the point where I can take that stuff for granted. I mean, if you look at my channel analytically, the only reason Vid 1 has been seen that much is because it's 3 years old; the newer videos have just a fraction of those views...and some of them never even hit 1K, so clearly it's not necessarily * me * that is popular...
All that is to say, yes, I still notice and care, even if on the outside it looks like I shouldn't...! ;v; And in general I think it's better to give the artist the benefit of the doubt and/or just like the post if you like it. You can support popular and un-popular artists at the same time; there's enough pie for everyone.