Yes and no. My comic is a really personal thing for me, a couple people have described it as a trauma comic because it's a vent of awful feelings and experiences I've had/seen over the years, so it's going to have bits of me and people I know in it. With that said I put traits, experiences and vices of people I know but never them in their entirety. A lot of MC stuff is mostly based on a mix of my experiences (first hand, second and third party experiences) and feelings, but I add a little of people I know in there. One character has the same vice as my mom's alcoholic ex, the second one has vices based on abused family members and smoking habits sooooo many people I know have.
Prominently I have a little of my mom, a couple of my coworkers, a couple cousins/uncles/aunts, some old friends on high school, people who's experiences and personalities have stuck in my mind in general.
The one most closely related to a full real person is one of my MC's partner, he's based off a mix of my dad and a certain serial killer who was known for being charismatic and popular before people found out what kind of "person" he was. The inclusion of the latter not being very loose and small, but take all that as you will.
Also I have a therapist character later on who's loosely based on a psychologist I had weekly sessions with a few years ago who was really nice.
I have not told anyone bits of themselves are in my comic, I've hardly told anyone I even have a comic, with the ones I do tell being really disinterested. If they did read it I doubt they would pick up on anything.