I'm unlikely to change my plot due to fan input, and I'd prefer not to become the kind of writer who would change their story to be different because somebody in the comments correctly predicted what will happen based on the trail of clues I've laid out and how well I've got across how my characters think, because that never really works well in comics I've read.
However, I might have to change my plot if say, a big movie or show came out with a really similar plot to what I wanted to do. It doesn't matter that my story is already all planned out, people would still think I was ripping it off, like how people treated the series "Zombie Powder" by Kubo Tight really badly by saying it was too much like Trigun, which came out just a little time before, or similarly Percy Jackson actually predates Harry Potter, but people call that a ripoff. It's annoying, but what can you do?
Also if a real-world tragedy happened and something in my comic was too similar in a way that'd feel insensitive, I'd potentially change things a bit.
If the comic got popular enough to have a decent sized community with fandom memes, I'd probably incorporate references to them in easter eggs. I regularly put in-jokes I have with my friends into backgrounds in comics I make anyway, and it's a fun way to show the readers that I value them.
I'd also potentially change elements of my world, characters etc. if there was critical backlash about how I was portraying marginalised groups from people in those groups. I can't please everyone, obviously, but if say, a lot of people of east-asian ethnicity were saying, "You're portraying your east-asian characters in a problematic way" I would definitely want to talk to them about that and perhaps look into changing how I do things, even if it meant changing elements of the world and plot.
Basically, I'm open to changing my comic if it makes it better, or avoids upsetting people. I have plenty of ideas, so I'm not scared that if I have to change it I'll never make anything else as good, but plot-wise I do feel like changing it is hard to do well if I've set up clues that clearly lead to a different outcome.