I don't post my comic here on tapas so I won't link it. But my character Isaac is missing a foot. He's got a peg leg!
This hasn't been too bad for him mostly. He's a ranger, so he uses a bow and arrow. The sole reason for this is it's obviously going to be a much better fighting method for him with his disability, although this is never explicitly stated in the comic. I wonder if people would ever think about it enough to put that together though.
It has hindered him a couple times. Early on he tripped because of it, although to be fair, I trip all the time and I am not disabled at all, just stupid. More recently, he is having a hell of a time with some muddy terrain because of it.
That's all that's really planned for it, little tedious things like that. It's not a big thing for him, it's been like this since he was a child (and destroyed it beyond fixing when he jumped out of a tree trying to fly). He was raised by bird people. He thinks he is a bird. The peg leg is the least of his problems.