I have multiple styles depending on the mood I'm wanting to portray in my comic! Style changes also work really great with expressions too!
I reserve my semi-realistic style for normal scenes and regular talking:


For something with more comedy, I'll use chibis or something cartoony:

As I mentioned earlier, changing styles is also really great for showing emotion!


Don't be afraid to experiment! I feel like getting the tone or thought across is better than having to stay with a set style. Changing it up also keeps your readers more engaged because they will never fully know what to expect!