If it would become so popular you won't be able to answer too much, it would be fair to stop and occasionally write something like "I am reading them all and unfortunately I am not able to answer, because there are thousands of comments under every page", if people won't get it, it's not really your problem. You can make special episodes once in a while answering questions from the comment section and feature some especially nice comments or something 
personal experience
(I had a short featured comic on Webtoons and it was only 3 episodes, it was impossible and quite useless to answer all of them, really, because these are literally people expressing their thoughts over this or that thing in the episode (usually they were quite similar too) , me and my writer only answered to some of them what were really nice, had questions about our other works or had questions that couldn't be answered any other way like "is there another episode in this")