Good slice of life stories thrive on empathy for the characters and what they're going through. That's why comedies are often more accessible than dramas.
Dramas tend to require more patience from the readers, but if they're done well and the reader has a good sense of empathy, they can be really gripping. But notably, most dramas work way better with little bits of comedy throughout, because jokes help you connect to the characters.
It's also why fantasy/sci fi dramas work well. You're pulled in by the world building first, and get to know the characters that way.
But yeah, there's no universal drama that will work for everyone. And seriousness/subject matter varies greatly. I personally don't like stories of constant suffering. I need something that is ultimately uplifting. I call those 'Upwards Drama', though it might have an official name already.