@oliver3 I've collected the first 3 chapters of my comic in print, and they were all coloured entirely in Clip Studio (or Manga Studio)! I did lose SOME of the brightness and intensity, but that was mainly in the very bright blue magical effects, and bright blue is an incredibly difficult colour to print, even when you do the original work in CMYK.
I made sure to get a proof-copy from the printer before I ordered the full print-run, so that I could take a good look at the pages in print and flip through the book - to see if I needed to make any changes. It turns out it looked just fine, even though my bright blue shades were a bit dimmed - but then, I work mostly in more natural colours, rather than the hyper-saturated and bright colour-spaces.
Not quite. Some things can be fixed with adjusting the colour balance and contrast, but some colours are pretty much unprintable. Bright teal, for example, and the brighest shades of green, or certain shades of violet. Basically, super-saturated colours will not look the same in print as they do on a computer monitor, regardless of how much you punch up the saturation.