Well, mine looks like this:
Usually, the menus on the lefthand side are a bit narrower than that; it just looks kind of wide right now because they're set up for my Cintiq 21UX, and this is a screenshot from my regular screen, which is smaller.
I adjusted the colours, because I find I get less eye-strain with a darker interface. I've also hidden the materials-menu on the righthand side as I hardly ever use them and they just take up space. Most of the other adjustments I've made are to specific brushes, tinker with some keyboard shortcuts (which I hardly ever use either - my non-drawing hand is usually occupied by a tea cup), and to add a few more tools to the selection-toolbar.