I used to do that thing where you use the lines on notebook paper to make boxes, and then draw in those. ^^
For a long time, notebook paper was the only thing I had to draw on...but when I got to middle school, where there was lots of blank printer paper available (to steal~), I started trying to be more professional. That was also around the time my family was gifted a printer/flatbed scanner combo, so I started scanning my art to make digital comics...with PowerPoint! 
Microsoft Office was my best friend back in those days (before you needed a subscription for it...), and I did EVERYTHING with PowerPoint. I knew that program inside and out, like the back of my hand, and I made some damn fine comics (and other visual media) with it for quite a few years.
Then I found Paint.NET, and I started doing actual digital artwork. But for comics, I still leaned on PowerPoint for formatting. It just had so many handy tools, and I felt so comfortable there...but eventually I decided I needed more artistic freedom (plus, they were starting to make radical interface changes with the new yearly updates, and I couldn't keep up), so it was time to leave the nest.
Deadeye was the first comic I did without help from PowerPoint, and it's only 3 years old, to give you some perspective. In fact, if you look closely at the first few pages, you can still see some WordArt (I was having a hard time letting go...we're okay now, though). ^^;
I kinda don't wanna do this, but here's a short sample of my PPT/P.Net fusion style...this was during my later days; most of the stuff in the pages was my own work at this point, even the speech bubbles. You almost can't tell I used PowerPoint at all.