Doomed One(s) is a comic about the great evil in a world with a prophecy and a chosen one, the great evil is destined to either destroy the world or be eraticated by the chosen one themself
that said, I had to title the series to resemble that exact fate, being chosen to essentially be a sacrifice
some titles I had were "Dark one", but I didn't like it, and it was too obvious on the protagonist (wanted to make people think the chosen one was the protagonist, then throw them in for a loop for the depressing life of being the dark lordess)
another was Unchosen one, but eck, it wasnt coming off the right way (like you werent chosen anymore)
I eventually came up with "The Doomed One(s)" since it was good contrast on the trope of "chosen one"
I removed the "The" eventually to have the title roll off the tongue more
Doomed was perfect, because in essense, the dark one (protagonist) is basically doomed, the (s) was because the dark one was not the only character destined to eratication, infact, there are several characters that are also "Doomed" and are the Dark One's loved ones, so they try everything in their power to protect their loved ones from an ill fate, this also keeps it vague as it may not just refer to the dark one and their loved ones...
mainly because... what if the dark one and their loved ones arent really doomed after all? what if the whole world is screwed because the dark one will succeed and destroy the world? who knows? I dont know 
doomed ones: do do edition (extras series) was a meta joke
acronym for Doomed ones is "DO", and this version of the series is showing off the pages before its remake, the really crummy ones... so DO DO
Really angsty was a more simple story, I made an edgy self insert joke character, so I wanted a title that reflected the edge, "this comic is really edgy" was one title, but "this comic is really angsty" was another title as well...it was originally gonna be a daily one off strip kind of ordeal...
eventually, I just stuck with "Really Angsty" because it used less words and it still got the idea across...