Here come the double edged sword of asking for advice on something like this. Only you know what you want for your stories and characters, and when you look to other people for what they would want, it muddies the waters.
For me and my comic, I wanted to make a tropey, cliched, Saturday morning cartoon style of comic that feels nostalgic for people around my age but could also appeal to those younger than me. The comic isn't speaking to a greater cause, doesn't take much to get into, and is pretty surface level at a glance. Those are things I wanted not only because I thought it would be easier to execute, but also because I absolutely love stories like that and I wanted to replicate that.
What's wrong with being self indulgent? You're making this comic because you want to, right? The whole endeavor is self indulgent, especially because you're not getting paid to do this, I assume.
It feels as though you're putting a lot of pressure on yourself to make something great, something you've mentioned before, and haven't considering doing something because you want to have fun with it.
Honestly, I seems as though you're using the forums as a crutch. You keep returning here for answers to questions we can't technically answer for you; only you have the answers to many of the questions you've posited.
So I ask you, what do you want for your story? Not what heights and successes do you want it to reach. Not what audiences want or previous partners want. Be honest, what do you even want?