Yeah, slices I get, at least when Photoshop lets me make them the right size, haha. The file-size cap gets me like every time so I have to chop the image in half and then slice again.
But I meant like the process of making the original file itself--you have to do a lot of panels separately, and often it makes it harder to make them cohesive. I'll end up with like 5 files open at the same time to make sure the panels match and all that, tossed into a folder aside, but it's so many different photoshop files taking up extra space...when there's got to be a simpler way. My vertical comics are just sooo big because every panel is like nearly a full page spread.