Well, if you're talking about totally starting off. The first webcomic I ever attempted was named 'We All Must be Daft' (I wanted to call it 'The Gods Must be Crazy', but I didn't want to take the title of the movie with the same name), in short it was going to be able previously mortal demigods rebelling against the a stagnant system that went on for whatever thousands of years, and create some surreal world or something. I dropped it because my mind was taken over by a sub-genre that was not present in the story, so I lost interest, which was probably for the best because I didn't have a clear idea of what I was doing with it.
But I remember before I deleted it I had about 10 subs or so, none of them ever tried to interact so I didn't have much of an attachment.
As for the first actually serious comic I made SJ, I honestly can't remember how many I had to start out with, but how I have about 350 or so; which is more than I ever imagined having on anything. For 'Void', when I started it on SJ I got probably 10 or more, now I have about 50. For here I just started out with 1, and now I have 27.
While subs are about as real as fast food, it's fun to analyze the numbers.