That would be horrific for me. At my day job, I work remotely over slack and zoom, and all our files are saved online too, so I wouldn't be able to work with that company any more without moving across the country.
For comics, I'd need to aim for working in print, which is something I've considered... but I'd have lost all my contacts in the industry, because most of them I only have email or social media addresses.
So I'd basically need to immediately look for work in print media, hoping that I can find contacts by attending events, and using the work I do have in print to show my skills. It'd be like when I started my career back in '08, but even less convenient, with the silver lining being that I've been published now and done work for big clients, which would help a lot.
I guess I'd socialise more locally. I have friends at the local tabletop meetup and things, and I'm a seasoned Dungeon Master who prefers running games in person... I'd miss all my online friends from around the world though.