The art is beeaauuuutiful! I really like the aesthetics.
About panel layout, sorry I can't help you since I've never done the 'vertical scrolling' layout myself.
The biggest opportunity for improvement that I see is to work on making the faces more expressive. So far they all have relatively neutral expressions (nothing wrong with neutral expressions, but sometimes its better to kick up the 'emotional volume' so to speak).
Another minor thing - in the second episode, in the panel where the light from the doorway shines on her face, it struck me that you re-used the same image from a couple panels before. I don't think there's any problem at all with re-using artwork in general (I do it myself sometimes), but in this particular case it was obvious enough to jump out at me and 'pull me out of the story'. I think it would have worked better with at least some minor changes to her expression so it feels like she's alive instead of a doll stuck in one position.
Overall though, woooow! 