I think my comic would suit western animation best, and I'd probably go for the classic "same intro and outro music" thing that they tend to do. I had this idea in my head of what the opening would be for the longest time, but then I heard this song, and...
Yeah, it's just perfect. Cute, minimalist, the lyrics are simple but fitting, and it's even the ideal length for a (non-anime) opening, no editing required.
And it would be really cool if this song played during like a "pivotal" episode or something: