I think that picking a popular genre might not actually be the best tactic, since...
a) SO MUCH COMPETITION. I launched a sci fi comic last week and ended up in New and Noteworthy right away, I think because the staff wants a range of genres in there and there aren't so many new sci fi comics to choose from.
b) You need to do something you're passionate about, or it'll end up being a chore.
Personally I'd love to see more sci fi, more historical fiction, and anything with an unusual stand-out art style.
