Yes, a very common feeling of dread when a post doesn't receive the same amount of reciprocated love that you put into making it.
My solution is I tend to try to forget about things once they're posted and I'm done advertising it all over social media, I stop thinking about it and start working on the next page to post. I, of course, will respond to comments and interactions that I do get from it, however, I don't let myself get wrapped up in it. I have too much work to let that happen haha
However! There are also ways and methods that artists can use to make themselves more appealing to engage with. I explored the concept a little bit in the first post of this thread.
The question is also brought up in this thread post too with lots of great advice:
I agree that Deviant Art has gone down hill, many artists are abandoning their profiles, and engagements are quite terrible there, but I think Tapastic yet again excels in this area. Interactions on Tapastic are great with so many happy positive readers that it's the main site I focus my efforts on for really having fun and being engaging.
Each site has their own social norms. Tumblr is more of a blog site so beyond likes, reblogs, and the occasional short comment string, it's also not the site for engagements for me. It's more of a place to post art process posts, WIPs, extra sketches, a few update links, etc.
This is another one of my favorite forum posts on building a social media presence you might find informative: