hmm... it depends on why and how its handled i spose?
like, in real life i do have to clarify & explain my gender to ppl (both ppl im assuming im a boy and also having the whole nonbinary talk) and have said 'im a lesbian' plenty, but in a story things that are totally normal out in the world can start to feel unnecessary and 'forced.' like, some people complained abt bill potts telling ppl she was a lesbian in dr who - those people are idiots, tbh, but i spose if a character kept having to explain their gender or sexuality to new characters the audience would have to ask 'why are they repeating this? are they trying to make a point? is this very central to the story?' (and this would go for anything. if a character had to keep reminding people he wasnt from france for some reason, itd be significant, or if they had to repeatedly tell people they were actually lao and not chinese.)
if you wanna tell a story thats not About Being Queer, its prolly best for characters identities to slot naturally into the story; there is the peripheral (or central) presence of your female leads girlfriend, or ex girlfriends, theres mentions of GSAs and transition medication - a queer persons queerness will likely touch lots of elements of their lives in subtle or major ways, from what they watch on tv to how they dress to who they keep as friends. the idea that all of us are 'just like' the cishets is a respectability ploy that ignores the lived experiences of most of us.
that said, particularly for nonbinary and gnc characters, sometimes you have to have the 'HEY DUDE, THIS ONES NOT A DUDE, STOP CALLING THEM A HE' scene, bc its the only way a portion of your audience will get it.
that all said, the characters in my comics dont have explicit labels; i feel like its a lot more about the lived experience than the category you place yourself in. Also, i write a lot of characters in setting where they wouldnt have access to those labels in the first place.