From what I know, there's plenty of comics that got printed copies but started as scroll comics and they still look great. It takes some rearranging, but it's definitely possible and it's getting more common now a days. I would say to go with whatever format you think best fits your story. Also, there's a reason scroll format is so popular on sites like Tapas, it's a lot easier to read scroll comics on the app, so there's that to keep in mind.