One of the biggest time sinks for me used to be trying to straighten out an image in Photoshop after scanning it in. I do almost all of my work analog - pencil, ink, and colour. So I have final art that needs to be scanned and touched up. But after I scanned it in, it was never quite straight. I would spend a lot of time rotating images by, say, 0.17 degrees, only to see that it's not quite straight enough, and then trying 0.18 degrees etc.
So I thought there must be a better way. I looked online and most people pointed to the Crop tool in Photoshop. The problem with that tool is that I needed to be zoomed way into the image to see my alignment markers, but the tool didn't let me pan or zoom out while in use. So that was a no go.
Then finally someone pointed out the Ruler tool. I could lay down an alignement line, zoom out and pan and zoom in again, adjust the positioning of the line until it was perfect, and THEN hit the "straighten" option in the toolbar at the top. What a life safer! This was so awesome. Something that used to take me 15 minutes or so now took less than a minute.
Hope this helps you too.