God, okay, so the funniest one would probably be one of three Arachnophobia comics, cause that was a three-parter and I loved it, but if we're talking stand-alone...
It has to be the Transition Lenses chapter. I went ham on that shading to help build focus, I love the concept and the sweat effect has probably been my favorite effects so far, despite its simplicity.
https://tapas.io/episode/1716659