I swapped my primary genre around from Action to LGBTQ+ and I don't regret the decision.
I originally launched Errant in "Action" because it made sense since Errant involves a lot of people with swords fighting monsters and stuff. When I got the chance to add secondary genres, I added LGBTQ+ and Fantasy because most of the characters are some flavour of LGBTQIA+ and I didn't want people to say I never warned them in advance.
But then there came this big influx of localised titles in the Action genre, and they were all...um... very different from what I was making. When Errant started, a good number of the top Action comics had either female leads or queer characters and themes and they were often kind of subverting the genre in some way, like The Witch's Throne or Lazy Snow Leopard. The vast majority of these new localised titles were about cishet male characters and were straightforward power fantasy stories. Errant no longer really fit in thematically or aesthetically with this category, so I simply swapped the order of my genres around to LGBTQ+, Action, Fantasy, choosing the page where Jules reveals they prefer "They" pronouns to do it.
At first, I thought I'd maybe made a mistake. My views and sub gain seemed to drop a bit for the first couple of weeks. In Action, on update days, I'd appear a lot higher up the ranking because while Action has more titles overall, I think it may have a lot more dead and discontinued series, and also it really seems like the active readership is more tightly constrained to a smaller number of titles there. So I was like "Oh no, fewer people are seeing my comic because it appears further down the ranking..."
But then things started to improve! Because it turns out that being lower in the ranking doesn't matter so much if people who do see it are more inclined to click your cover and to read your comic because the audience browsing the genre are more the sort of people who want to read that kind of content!
And then the best thing possible happened. A new Tapas Original released called Pandora's Devils. The existence of Pandora's Devils is such a big boon for me because it's a comic in the LGBTQ+ category about a majority female cast, with queer themes, bold colourful art and is a modern Action Fantasy with light satirical elements. So it's like, oh no! you ran out of Pandora's Devils to read? You're browsing the LGBTQ+ category and yes, hello there, Errant is here to supply you with more of similar themes! It really helped me feel like Errant belonged in that category when a Tapas original with a similar vibe was added. 
I'd definitely advise people to look at the sort of things popular in genres and see which genre has popular titles that more closely resemble the look and feel of your comic.