I suspect this depends on the kind of readers you want to attract. I'm more of a "masterpiece-a-week" type I guess, so I do have a clear bias in that direction x) - but that's my personal preference with comics I read too.
If I had to create a "reader profile" for myself, it would be something like this:
I've always enjoyed consuming media that is slow-moving and elaborate. Stories that make me think- where I can go back over the same pages and notice something new and different every time I re-read them, or better yet- where I realize the narrative was so well-planned that I notice hints and foreshadowing on previous pages I might otherwise have missed, or even read a previous scene in a completely different way now that I've acquired new information from later pages. So of course I aspire to make something like that myself.
If I see a webcomic that updates often, with a nicely done art style suited to fast-paced drawing- but the individual pages lack substance (i.e. five pages spent on a character doing something as mundane as getting up, turning off an alarm clock and going to school- or random character banter about lunch) I'm probably not going to read it. Similarly, if I'm choosing between spending my time reading a comic that looks like it has considerable thought put into every single page vs. a comic where the art "works" as a vehicle for the story, but that's about it- even if the latter comic has more pages out and updates more often- unless something about the subject matter really hooks me, I'm always going to choose the first one.
And I know that as a reader, if I like something, I really like it- meaning I won't be put off by long wait times (unless we're talking something ridiculous, like years here). I'm not going to lose interest and unsubscribe, simply because a comic I enjoy hasn't updated in a week- perhaps even a month or two of hiatus. If I did, wouldn't that suggest that my interest was pretty shallow and circumstantial in the first place? (i.e. I just thought it was pretty and hit the subscribe button to check it out later)
So this is me, a type of reader.
There are other types of readers out there. For example, I have a friend who always tells me he has a short attention span, and so prefers fast-paced media that makes him laugh. His interests tend to fluctuate a lot more, and he jumps from one favorite thing to another more often. He's more likely to give up on something, or grow bored if it doesn't go out of its way to maintain his interest. This doesn't make my friend a "worse" reader, but I personally wouldn't work to cater to readers like him because that just doesn't make sense for the type of story I'm trying to tell.
I'm sure there are many other "types" of readers out there you can conceive of. So perhaps the best way to answer your question is to think about what kind of story you want to tell- then what kind of reader would most likely enjoy this kind of story- and finally, cater to that. If you're basically the type of reader you want to attract, because you're writing a story you would want to read- consider your own reading habits. What makes you want to read a story? What turns you off a story or makes you grow bored of it and give it up? And then use that as your starting point for what to do and what to avoid.