Depends on a lot! Pacing of your comic, your personal priorities for your comic, the actual numbers involved, etc etc.
For instance, as a reader, I'd prefer the option of more panels per page with a one-page-a-week update over the option of fewer panels per page for a 2x a week update. But if more panels per page means only one page every three weeks, I don't think it would be worth it anymore.
And of course, slower updates means slower growth (even if it makes the updates better), but that can be worth it if it's necessary to what you want for your story!