I like to be in the middle, I guess...like, it's okay for things to be a little unrealistic if the story reads better that way. In the grand scheme of things, the overall story is much more important than the little odds and ends.
But if it's kind of common knowledge that certain things just don't happen (like monologuing after you've been stabbed through the heart. THROUGH THE HEART) and you write them anyway, you're just abusing your readers' suspension of disbelief.
Hospital inaccuracies, for instance, are forgivable: most people will go most of their lives without being familiar with what goes on inside a hospital, and what all the rules are. Personally, I've only been in a hospital maybe 6 or 7 times in my life, and never longer than a few hours...despite the fact that my own mother works as a nurse, I'm pretty clueless. =/
When it comes to things like jumping out 8-story windows, though...I mean, most 6-year-olds know what'll happen to you if you leap off a skyscraper or get your head cut off; no one's gonna go "oh, poetic license" when you pretend something other than death might be the outcome...
TL;DR Write whatever you want; drama rocks. But if your story does indeed take place in the real world, watch your extremes.