As someone who drew a lot, then stopped for several years, it was hard to get going again. There are also some unique challenges that may come up.
I admit, I lost A LOT of my skill during my time away. My hand lost some of its control with a pen and pencil, art programs changed, and I had to work to get back to where I was before, and re-familiarize myself with the tools I used to use.
As for the comic, I had a comic that I spent a good 5 years working on before I quit. I really wanted to get back on it, and continue the story that I had previously abandoned. Unfortunately, I had grown as a person/adult during my time away, and I could not continue the old comic because it became foreign to me. It was difficult when I finally made the choice to let the domain expire, because I realized that I had to move on.
Comics are time and energy investments, so if you decide that is what you want to do again, then have at it!