I'm in the same boat: I'm currently using a handwriting font from my own handwriting but it's... really not very good imo xD gonna finish out the current season with it and then maybe go back and edit it to a different font later. (I'm wanting to print some copies eventually so it's worth the fix, I think).

^ Meh.
As far as actual hand lettering goes, I just recently did a 10-page short story where I hand lettered everything, and I think it turned out pretty nice! I used a trick I saw someone suggest on this forum a while back, where basically I typed out all the text and then turned the opacity down and hand lettered over it, which helps keep the kerning consistent and the text aligned and straight xD then once it's written, you can lasso it and move or rotate it around as needed.
I'm going to take another stab at making a better handwriting font for the next season of my comic, but if it's still not great I may be moving this direction for all of my stuff afterwards too xD
(For sound effects and such, i typically just write them out manually, and lately just apply a stroke effect to the outside of the layer. I've been pretty happy with how that's been turning out!