I personally like the marker one better because the colors feel softer and more natural. The digital one is a little jarring. For instance, I'm a person who really loves purple. I use purple as one of the main colors in my webcomic... but it can be kind of an eyestrainer if used too saturated. Which can work in some cases, if you're trying to make something look other worldly or creepy, there's a reason Disney baddies usually have purple and green color schemes, but if saturated versions are used on regular things that aren't the focus of the panel it can be distracting.
The first purple is straight off the photoshop palette purple. The second is pulled from the wall in Candace's room in your comic. The third and fourth are pulled from the walls in a recent page of my comic. In this context they look kind of dull, but when surrounded by other colors they read as purple without pulling the eye away from the focal point of the panel or jumping up to the foreground of the image. I also usually tamper my purples with a little more blue or a little more pink, which tends to seem more natural than true purple. The same goes for other colors. Like making green a little more yellow or a little more blue can make it more natural looking.
Also shading with gray or black can make the colors look a little muddy. I did a quick re-color like @stnmaren did and I also hope you don't mind.
This doesn't really take into account that she's in a dark room, because I wanted to do just a general coloring sample, but I basically just shaded the color with a darker version of the same color, and a warmer color in this case since she's a cute character and warm colors are kind of cuter, if that makes sense. I did change her hair to a less yellow-y yellow, but the base skin tone is the same as in your original, but by shading with a warmer skin color her whole face gets a more lively tone to it.
Okay, I'm gonna stop because I could talk shop about coloring all day, but I hope some of that was helpful?
