I definitely agree with @Simon_M, even though it's a slight tangent from the discussion of popularity. It's very easy to draw parallels to television in this regard. After all, what is Keeping Up With the Kardashians if not an autobiopic slice-of-life tv show? Look how popular it is compared to a television show like The Americans or The Leftovers, which critics tend to think might have ground to stand on as being as good/better than The Wire, Breaking Bad, etc. The Americans and The Leftovers portray deep cultural significance, a fight for the soul of what it means to be a person living in this world, dealing with tragedy and conflict and difficult decisions. Kardashians, meanwhile, waters life down, doesn't challenge the viewers to think, re-enforces shallow values, doesn't value intelligence, etc.
One is objectively better than the other, and the other is objectively more popular. Things tend to work like that. Is Kardashians low effort, though? Absolutely not. They have to live with a television crew following them around all the time, have to be very purposeful in how they portray their lives as their lives = their branding, have to constantly be moving and busy. They also don't have to be thoughtful (or thought-provoking) towards writing, literature, directing, acting, philosophy, symbolism, etc. If future generations look back at Kardashians as the benchmark of our era, they will believe that we were a time of anti-intellectualism and shallow consumerism ... but that's not really the (full) truth. If future generations look back at The Americans, they will understand that we lived in a complicated time with a lot of conflict where the problems and people of the world weren't black and white -- they were just people, doing their best to protect the things they believe in.
TL;DR In terms of comics ... no, not every comic needs to try to be saying something big and important. Humor is important. Slice-of-life can be important if it helps (particularly young) people learn how to accept themselves. There are reasons why some genres are more popular with the younger demographic that makes up a majority of online content readership. But I do wish that more folks cared to be challenged and forced to think by the things that they read, much in the same way that I wish The Leftovers was watched by more people than the Kardashians. That's just my perspective, though, and while I do believe quality can be objective, my perspective is certainly subjective.