I've not received much negative response! Sometimes you can tell folks don't get it or aren't really into that scene -- though I have a lot of buffers before I describe webcomics specifically, because I think there's some value in being careful of whom you trust with your passion.
"So you do art?"
"Yeah, I'm a cartoonist!" (the first point where people can go "oh that's cool" and end the convo)
"Oh, what kind of cartoons do you do?"
"Actually, I draw my own comic books!" (the second point someone can say "oh that's cool" and leave it at that)
and if they ask additional questions, then I might explain how webcomics and patreon and self-publishing work, but at that point it's usually someone who's at least a little interested. I've had people who are really stunned/impressed? by the amount of time involved in creating these things, people who think that any kind of money for art is "lucky" (I mean, I guess, but when you say it that way it sure sounds disparaging) but the majority of people unfamiliar with webcomics are like.... intrigued by it, as a look behind the scenes? Like almost a "whoa, that's cool, I didn't know that's how it works" kind of reaction.
For coworkers and other folks I interact with more, they would want to check out my work, and it would often just result in "I looked at your art and it's really good." I had one coworker buy some books, convinced that they'd be valuable someday when I'm rich and famous. I think just one guy at my old job actually read my journal comic and really enjoyed it (but I was a lil nervous about giving out my journal comic at work since my workplace featured prominently in my journal comic). My fantasy comic tends to be a little more intimidating, and folks who aren't really into that scene don't tend to try to read it, they just express that it's pretty and leave it at that!